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Cholestyramine has been reported to reduce intestinal absorption of fat-soluble vitaminsas such it may impair intestinal absorption of Rocaltrolsee WARNINGS and PRECAUTIONSGeneral

A relationship of functional antagonism exists between vitamin D analogueswhich promote calcium absorptionand corticosteroidswhich inhibit it.

If the patient is switched from a long acting vitamin D preparatione.gergocalciferolvitamin D 2or colecalciferolto calcitriolit may take several months for the ergocalciferol level in the blood to return to the baseline valuethereby increasing the risk of hypercalcaemiasee section 4.9

Since calcitriol is the most potent active metabolite of vitamin D 3pharmacological doses of vitamin D and its derivatives should be withheld during treatment with Rocaltrolcalcitriolto avoid possible additive effects and hypercalcemiasee WARNINGS

Supravalvular aortic stenosis has been produced in foetuses by near-fatal oral doses of vitamin D in pregnant rabbitsThere is no evidence to suggest that vitamin D is teratogenic in humans even at very high dosesRocaltrol should be used during pregnancy only if the benefits outweigh the potential risk to the foetus.

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your doctor will need to make regular measurements of the calcium level in your blood while you are taking rocaltrol.

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